LSP is one of the very few academic groups operating a comprehensive HTE workflow for organometallic catalysis. In particular, in the framework of long-term collaborations with leading HTE tool manufacturers (former Symyx Technologies, later Freeslate and now Unchained Labs), polyolefin producers (mainly Dow Chemical and SABIC) and private-public research consortia (Dutch Polymer Institute, DPI), we pioneered the application of integrated experimental HTE methodologies for catalyst/process optimization studies.
The workflow consists of:
- Freeslate Parallel Pressure Reactor (PPR48). This setup, integrally contained in a triple MBraun LabMaster glovebox, features 48 reaction cells arrayed in 6 eight-cell The cells are controlled individually with online monitoring of temperature, pressure, and differential and integral conversions of gaseous monomers.
- Freeslate Extended Core Module (XCM2). This platform for parallel organic and organometallic synthesis is also housed in a triple MBraun LabMaster glovebox, and enables the robotic handling, weighing, and dispensing of solid, liquid and slurry air/moisture-sensitive compounds according to fully automated
- MBraun Solvent Purification System (SPS-5). This 5-line system operates by flowing the solvents of interest in sequence through a de-oxygenation column (fixed bed of an activated-Cu catalyst) and a drying column (fixed bed of A4 zeolites). Residual O2 and H2O levels are below 1 ppmv. The purifiedsolvents can be dispensed through Schlenk lines or into an integrated
- Bohdan Balance Automator, for robotic
Main Equipment – High – Throughput Experimentation (HTE)